* in no particular order and as brief as possible...
AIR is Everywhere
Not really, but it's circulating. AIR is definitely on Android, just check out any of the 50+ Android hands-on labs and sessions. And it's now on BlackBerry, especially the PlayBook (w/ AIR-based OS). It's also on Samsung's Galaxy Tab. And one of their... uh... Blu-Ray players. And a Samsung TV early next year.
The takeaway - by MAX 2011, AIR will be much closer to "everywhere" which will be awesome.
The challenge - will AIR be on PS3 and XBox?
Flash Builder / Burrito / Hero
These are the true-blue heros behind AIR's growing significance. Burrito is buggy but has a to-die-for feature: USB to Android deployment for testing. Couple of steps and my app is ON MY FREAKING PHONE! Pow! And the new Hero SDK makes my app feel more or less natural on my phone.
The takeaway - I'm making Android apps, stat.
The challenge - how to get Hero-based AIR apps on my real devices: my iPhone and iPad.